{"id":24408,"date":"2019-08-07T00:00:00","date_gmt":"2019-08-07T04:00:00","guid":{"rendered":"https:\/\/www.diabete.qc.ca\/la-recherche\/transplantation-dilots-pancreatiques-2\/"},"modified":"2023-06-07T16:23:21","modified_gmt":"2023-06-07T20:23:21","slug":"transplantation-of-pancreatic-islets","status":"publish","type":"page","link":"https:\/\/www.diabete.qc.ca\/en\/research\/research-news\/transplantation-of-pancreatic-islets\/","title":{"rendered":"Transplantation of pancreatic islets"},"content":{"rendered":"<div class=\"classic-block\">The first islet transplant was performed at Montreal\u2019s McGill University Health Centre (MUHC) in 2015. The woman with type 1 diabetes who had the procedure had previously had a kidney transplant and an unsuccessful pancreas transplant. Her diabetes had become very unstable with multiple episodes of hypoglycemia, so she could no longer be left on her own.<\/p>\n<p>Thanks to years of experience and the development of new technologies, Dr. Steven Paraskevas and his team were able to collect islets of Langerhans cells from the pancreas of a deceased compatible donor. Insulin is produced by the beta cells, which make up 65% to 80% of the islets. These islets were then injected into the portal vein of the woman\u2019s liver through a small catheter inserted into the abdomen under local anesthesia. A few days later, the woman began to produce insulin on her own.<\/p>\n<p>Several weeks later, she became completely free of insulin injections. Since then, two other similar transplants have been successfully performed on patients with severe type 1 diabetes. According to recent studies, five years after having this kind of transplant, 60% of the recipients still do not need insulin injections.<\/p>\n<p>Priority is given to people with diabetes who have severe, recurring hypoglycemia despite good adherence to their treatment. These people must also have good kidney function or have had a successful kidney transplant.<\/p>\n<p>It is important to mention that the number of transplants depends on the availability of pancreases from deceased donors. In addition, islets transplant recipients must take a long-term anti-rejection (immunosuppressant) drug that has a number of risks and adverse side effects. It is therefore very important to weigh the potential benefits of a transplant against these risks.<\/p>\n<p>The MUHC is the only centre in Eastern Canada and one of a dozen centres in North America capable of isolating and transplanting pancreatic islets. Dr. Paraskevas hopes to have islets transplantation approved as a treatment in Qu\u00e9bec so that more transplants can be done.<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The first islet transplant was performed at Montreal\u2019s McGill University Health Centre (MUHC) in 2015. The woman with type 1 diabetes who had the procedure had previously had a kidney transplant and an unsuccessful pancreas transplant. Her diabetes had become very unstable with multiple episodes of hypoglycemia, so she could no longer be left on&hellip;<\/p>\n","protected":false},"author":1,"featured_media":14881,"parent":24275,"menu_order":64,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_relevanssi_hide_post":"","_relevanssi_hide_content":"","_relevanssi_pin_for_all":"","_relevanssi_pin_keywords":"","_relevanssi_unpin_keywords":"","_relevanssi_related_keywords":"","_relevanssi_related_include_ids":"","_relevanssi_related_exclude_ids":"","_relevanssi_related_no_append":"","_relevanssi_related_not_related":"","_relevanssi_related_posts":"15782,8066,11781,68,12763,15753","_relevanssi_noindex_reason":"","footnotes":""},"class_list":["post-24408","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/pages\/24408","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/comments?post=24408"}],"version-history":[{"count":7,"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/pages\/24408\/revisions"}],"predecessor-version":[{"id":29516,"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/pages\/24408\/revisions\/29516"}],"up":[{"embeddable":true,"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/pages\/24275"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/media\/14881"}],"wp:attachment":[{"href":"https:\/\/www.diabete.qc.ca\/en\/wp-json\/wp\/v2\/media?parent=24408"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}